Publications

 

2022

Tang T, Tan Q, Han S, Diemar A, Löbner K, Wang H, Schüß C, Behr V, Mörl K, Wang M, Chu X, Yi C, Keller M, Kofoed J, Reedtz-Runge S, Kaiser A, Beck-Sickinger AG, Zhao Q, Wu B. Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. Sci Adv. 2022; 8(18):eabm1232. doi: 10.1126/sciadv.abm1232. 

Groß VE, Gershkovich MM, Schöneberg T, Kaiser A, Prömel S. NanoBRET in C. elegans illuminates functional receptor interactions in real time. BMC Mol Cell Biol. 2022;23(1):8. doi: 10.1186/s12860-022-00405-w. 

2021

Gershkovich MM, Groß VE, Vu O, Schoeder CT, Meiler J, Prömel S, Kaiser A. Structural Perspective on Ancient Neuropeptide Y-like System reveals Hallmark Features for Peptide Recognition and Receptor Activation. J Mol Biol. 2021;433(13):166992. doi: 10.1016/j.jmb.2021.166992. 

Tang T, Hartig C, Chen Q, Zhao W, Kaiser A, Zhang X, Zhang H, Qu H, Yi C, Ma L, Han S, Zhao Q, Beck-Sickinger AG, Wu B. Structural basis for ligand recognition of the neuropeptide Y Y2 receptor. Nat Commun. 2021;12(1):737. doi: 10.1038/s41467-021-21030-9. 

Ziffert I, Kaiser A, Hoppenz P, Mörl K, Beck-Sickinger AG. Shuttling of Peptide-Drug Conjugates by G Protein-Coupled Receptors Is Significantly Improved by Pulsed Application. ChemMedChem. 2021;16(1):164-178. doi: 10.1002/cmdc.202000490.

2020

Vogel A, Bosse M, Gauglitz M, Wistuba S, Schmidt P, Kaiser A, Gurevich VV, Beck-Sickinger AG, Hildebrand PW, Huster D. The Dynamics of the Neuropeptide Y Receptor Type 1 Investigated by Solid-State NMR and Molecular Dynamics Simulation. Molecules. 2020;25(23):5489. doi: 10.3390/molecules25235489.

Kaiser A, Coin I. Capturing Peptide-GPCR Interactions and Their Dynamics. Molecules. 2020;25(20):4724. doi: 10.3390/molecules25204724. 

Laugwitz JM, Haeri HH, Kaiser A, Krug U, Hinderberger D, Beck-Sickinger AG, Schmidt P. Probing the Y2 Receptor on Transmembrane, Intra- and Extra-Cellular Sites for EPR Measurements. Molecules. 2020;25(18):4143. doi: 10.3390/molecules25184143.

Krug U, Gloge A, Schmidt P, Becker-Baldus J, Bernhard F, Kaiser A, Montag C, Gauglitz M, Vishnivetskiy SA, Gurevich VV, Beck-Sickinger AG, Glaubitz C, Huster D. The Conformational Equilibrium of the Neuropeptide Y2 Receptor in Bilayer Membranes. Angew Chem Int Ed Engl. 2020;59(52):23854-23861. doi: 10.1002/anie.202006075. 

Ziffert I, Kaiser A, Babilon S, Mörl K, Beck-Sickinger AG. Unusually persistent Gαi-signaling of the neuropeptide Y2 receptor depletes cellular Gi/o pools and leads to a Gi-refractory state. Cell Commun Signal. 2020;18(1):49. doi: 10.1186/s12964-020-00537-6. 

Kaiser A, Wanka L, Ziffert I, Beck-Sickinger AG. Biased agonists at the human Y1 receptor lead to prolonged membrane residency and extended receptor G protein interaction. Cell Mol Life Sci. 2020;77(22):4675-4691. doi: 10.1007/s00018-019-03432-7. 

2019

Gershkovich MM, Groß VE, Kaiser A, Prömel S. Pharmacological and functional similarities of the human neuropeptide Y system in C. elegans challenges phylogenetic views on the FLP/NPR system. Cell Commun Signal. 2019;17(1):123. doi: 10.1186/s12964-019-0436-1.

Bech EM, Kaiser A, Bellmann-Sickert K, et al. Half-Life Extending Modifications of Peptide YY3-36 Direct Receptor-Mediated Internalization. Mol Pharm. 2019;16(8):3665-3677. doi:10.1021/acs.molpharmaceut.9b00554

Kögler LM, Stichel J, Kaiser A, Beck-Sickinger AG. Cell-Free Expression and Photo-Crosslinking of the Human Neuropeptide Y2 Receptor. Front Pharmacol. 2019;10:176. doi:10.3389/fphar.2019.00176

Bender BJ, Vortmeier G, Ernicke S, et al. Structural Model of Ghrelin Bound to its G Protein-Coupled Receptor. Structure. 2019;27(3):537-544.e4. doi:10.1016/j.str.2018.12.004

2018

Wanka L, Babilon S, Kaiser A, Mörl K, Beck-Sickinger AG. Different mode of arrestin-3 binding at the human Y1 and Y2 receptor. Cell Signal. 2018;50:58-71. doi:10.1016/j.cellsig.2018.06.010

Yang Z, Han S, Keller M, et al. Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor. Nature. 2018;556(7702):520-524. doi:10.1038/s41586-018-0046-x

Kaiser A, Hempel C, Wanka L, Schubert M, Hamm HE, Beck-Sickinger AG. G Protein Preassembly Rescues Efficacy of W6.48 Toggle Mutations in Neuropeptide Y2 Receptor. Mol Pharmacol. 2018;93(4):387-401. doi:10.1124/mol.117.110544

Schmidt P, Bender BJ, Kaiser A, et al. Improved in Vitro Folding of the Y2 G Protein-Coupled Receptor into Bicelles. Front Mol Biosci. 2018;4:100. doi:10.3389/fmolb.2017.00100

2017

Schmidt P, Bender BJ, Kaiser A, et al. Improved in Vitro Folding of the Y2 G Protein-Coupled Receptor into Bicelles. Front Mol Biosci. 2018;4:100. doi:10.3389/fmolb.2017.00100

Schrottke S, Kaiser A, Vortmeier G, et al. Expression, Functional Characterization, and Solid-State NMR Investigation of the G Protein-Coupled GHS Receptor in Bilayer Membranes. Sci Rep. 2017;7:46128. Published 2017 Apr 7. doi:10.1038/srep46128

Burkert K, Zellmann T, Meier R, et al. A Deep Hydrophobic Binding Cavity is the Main Interaction for Different Y2 R Antagonists. ChemMedChem. 2017;12(1):75-85. doi:10.1002/cmdc.201600433

2016 and earlier

Burkert K, Zellmann T, Meier R, et al. A Deep Hydrophobic Binding Cavity is the Main Interaction for Different Y2 R Antagonists. ChemMedChem. 2017;12(1):75-85. doi:10.1002/cmdc.201600433

Schönauer R, Kaiser A, Holze C, et al. Fluorescently labeled adrenomedullin allows real-time monitoring of adrenomedullin receptor trafficking in living cells. J Pept Sci. 2015;21(12):905-912. doi:10.1002/psc.2833

Kaiser A, Müller P, Zellmann T, et al. Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y₂ Receptor Binding and Activation. Angew Chem Int Ed Engl. 2015;54(25):7446-7449. doi:10.1002/anie.201411688

Mäde V, Bellmann-Sickert K, Kaiser A, Meiler J, Beck-Sickinger AG. Position and length of fatty acids strongly affect receptor selectivity pattern of human pancreatic polypeptide analogues. ChemMedChem. 2014;9(11):2463-2474. doi:10.1002/cmdc.201402235

Witte K, Kaiser A, Schmidt P, et al. Oxidative in vitro folding of a cysteine deficient variant of the G protein-coupled neuropeptide Y receptor type 2 improves stability at high concentration. Biol Chem. 2013;394(8):1045-1056. doi:10.1515/hsz-2013-0120

Schreiber A, Schramm P, Hofmann HJ. How many hydrogen-bonded α-turns are possible?. J Mol Model. 2011;17(6):1393-1400. doi:10.1007/s00894-010-0830-5